Article
Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis.
Arthritis and rheumatism - 15 Dec 2007
Guis Sandrine, Balandraud Nathalie, Bouvenot Julien, Auger Isabelle, Toussirot Eric, Wendling Daniel, Mattei Jean-Pierre, Nogueira Leonor, Mugnier Benedicte, Legeron Pierre, Landt Olfert, Serre Guy, Roudier Jean, Roudier Chantal
Abstract excerpt
OBJECTIVE: To determine whether the -308 A/G tumor necrosis factor alpha (TNFalpha) gene polymorphism can predict the outcome of etanercept therapy in 86 patients with rheumatoid arthritis (RA), as already observed in patients treated with infliximab. METHODS: Eighty-six RA patients treated with etanercept were genotyped for -308 A/G TNFalpha gene polymorphism by polymerase chain reaction and melting curve...
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