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Article

Molecular imaging genetics of methylphenidate response in ADHD and substance use comorbidity.

Synapse (New York, N.Y.) - 1 Feb 2011

Szobot Claudia M, Roman Tatiana, Hutz Mara H, Genro Júlia P, Shih Ming Chi, Hoexter Marcelo Q, Júnior Neivo, Pechansky Flávio, Bressan Rodrigo A, Rohde Luis A P

Abstract excerpt

PURPOSE: Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders (SUDs) are highly comorbid and may share a genetic vulnerability. Methylphenidate (MPH), a dopamine transporter (DAT) blocker, is an effective drug for most ADHD patients. Although dopamine D4 receptor (DRD4) and dopamine transporter (DAT1) genes have a role in both disorders, little is known about how these genes influence brain...

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Share to Dopamine Plasma Membrane Transport Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylphenidate

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Share to Receptors, Dopamine D4

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Share to Tomography, Emission-Computed, Single-Photon

Source

Identifiers

PMID: 20593420
DOI: 10.1002/syn.20829

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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