Evaluation of dopamine transporter gene variations in Turkish children with attention deficit hyperactivity disorder treated with methylphenidate adverse effects.

doi:10.1080/14622416.2026.2706504

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Article

Evaluation of dopamine transporter gene variations in Turkish children with attention deficit hyperactivity disorder treated with methylphenidate adverse effects.

Pharmacogenomics - 1 Jul 2026

Pekkoc-Uyanik Kubra Cigdem, Bayindir Melik Yigit, Akdemir Muhammet Fatih, Aydin Okuyan Aybike, Tarakcioglu Mahmut Cem, Ozyazgan Sibel, Todurga Seven Zeynep Gizem

Abstract excerpt

AIM: Attention-deficit hyperactivity disorder (ADHD) is a common childhood psychiatric disorder, with methylphenidate (MPH) as the first-line treatment. MPH primarily exerts its effects by inhibiting the dopamine transporter (DAT); therefore, variants in the DAT1 gene may affect susceptibility to its adverse effects. METHODS: This study included 47 children and adolescents diagnosed with ADHD according to...

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Topics

Humans
Attention Deficit Disorder with Hyperactivity
Methylphenidate
Dopamine Plasma Membrane Transport Proteins
Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adolescent

Female

Male

Central Nervous System Stimulants

Turkey

Polymorphism, Single Nucleotide

Genetic Association Studies

Genotype

Source

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Identifiers

PMID: 42495982
DOI: 10.1080/14622416.2026.2706504
PMCID: PMC13556950

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