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Article

Stem cells in cancer: instigators and propagators?

30 Jun 2010

Abstract excerpt

There is growing realization that many - if not all - cancer-cell populations contain a subpopulation of self-renewing stem cells known as cancer stem cells (CSCs). Unlike normal adult stem cells that remain constant in number, CSCs can increase in number as tumours grow, and give rise to progeny that can be both locally invasive and colonise distant sites - the two hallmarks of malignancy. Immunodeficient mouse...

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PMID: 20592182
DOI: 10.1242/jcs.054296

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