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Article

Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations.

Cancer research - 1 Oct 2015

Rycaj Kiera, Tang Dean G

Abstract excerpt

A tumor originates from a normal cell that has undergone tumorigenic transformation as a result of genetic mutations. This transformed cell is the cell-of-origin for the tumor. In contrast, an established clinical tumor is sustained by subpopulations of self-renewing cancer cells operationally called cancer stem cells (CSC) that can generate, intraclonally, both tumorigenic and nontumorigenic cells. Identifying...

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Identifiers

PMID: 26292361
DOI: 10.1158/0008-5472.CAN-15-0798
PMCID: PMC4756645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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