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Complexity of cancer stem cells

26 Nov 2012

Abstract excerpt

Heterogeneity of tumor tissue has been accounted for in recent years by a hierarchy-based model in which cancer stem cells (CSCs) have the ability both to self-renew and to give rise to differentiated tumor cells and are responsible for the overall organization of a tumor. Research into CSCs has progressed rapidly and concomitantly with recent advances in the biology of normal tissue stem cells, resulting in the...

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PMID: 23180591
DOI: 10.1002/ijc.27961

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