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Cancer stem cells: problems for therapy?

27 Sept 2010

Abstract excerpt

Many, if not all, tumours contain a sub-population of self-renewing and expanding stem cells known as cancer stem cells (CSCs). The symmetric division of CSCs is one mechanism enabling expansion in their numbers as tumours grow, while epithelial-mesenchymal transition (EMT) is an increasingly recognized mechanism to generate further CSCs endowed with a more invasive and metastatic phenotype. Putative CSCs are...

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PMID: 21125672
DOI: 10.1002/path.2793

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