Article
The impact of the d3-growth hormone receptor (d3-GHR) polymorphism on the therapeutic effect of growth hormone replacement in children with idiopathic growth hormone deficiency in Poland.
Neuro endocrinology letters - 1 Sept 2016
Szmit-Domagalska Justyna, Petriczko Elżbieta, Drozdzynska Marta, Adler Grazyna, Horodnicka-Jozwa Anita, Ciechanowicz Andrzej, Walczak Mieczysław
Abstract excerpt
OBJECTIVES: The human growth hormone receptor (GHR) exon 3 deletion (d3) polymorphism has been reported to be associated with the responsiveness to growth hormone (GH) therapy. This study aimed to: (a) assess the frequency of this polymorphism in a group of Polish children with idiopathic growth hormone deficiency (IGHD) and (b) analyze their response to GH therapy. METHODS: The study group consisted of 67...
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