Article
Influence of growth hormone (GH) receptor deletion of exon 3 and full-length isoforms on GH response and final height in patients with severe GH deficiency.
The Journal of clinical endocrinology and metabolism - 1 Mar 2008
Räz Barbara, Janner Marco, Petkovic Vibor, Lochmatter Didier, Eblé Andrée, Dattani Mehul T, Hindmarsh Peter C, Flück Christa E, Mullis Primus E
Abstract excerpt
CONTEXT: A polymorphism of the GH receptor (GHR) gene resulting in genomic deletion of exon 3 (GHR-d3) has been associated with responsiveness to GH therapy. However, the data reported so far do vary according to the underlying condition, replacement dose, and duration of the treatment. OBJECTIVE...
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