Article
Growth hormone (GH) pharmacogenetics: influence of GH receptor exon 3 retention or deletion on first-year growth response and final height in patients with severe GH deficiency.
The Journal of clinical endocrinology and metabolism - 1 Mar 2006
Jorge Alexander A L, Marchisotti Frederico G, Montenegro Luciana R, Carvalho Luciani R, Mendonca Berenice B, Arnhold Ivo J P
Abstract excerpt
CONTEXT: A polymorphism in GHR gene, the presence or absence of exon 3, has been shown to influence the 1- and 2-yr growth responses to human recombinant GH (hGH) therapy in children without GH deficiency (GHD). OBJECTIVE: The objective of this study was to assess the influence of GHR-exon-3 genotype on the short and long-term response to hGH therapy in children with GHD. SETTING: The study was conducted in the...
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