Article
The -202 A allele of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism is associated with higher IGFBP-3 serum levels and better growth response to growth hormone treatment in patients with severe growth hormone deficiency.
The Journal of clinical endocrinology and metabolism - 1 Feb 2009
Costalonga Everlayny Fiorot, Antonini Sonir R, Guerra-Junior Gil, Mendonca Berenice Bilharinho, Arnhold Ivo J P, Jorge Alexander A L
Abstract excerpt
CONTEXT: Genetic factors that influence the response to recombinant human GH (rhGH) therapy remain mostly unknown. To date, only the GH receptor gene has been investigated. OBJECTIVE: The aim of the study was to assess the influence of a polymorphism in the IGF-binding protein-3 (IGFBP-3) promote...
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