Article
Engineering allosteric regulation into the hinge region of a circularly permuted TEM-1 beta-lactamase.
Protein engineering, design & selection : PEDS - 1 Sept 2010
Mathieu Valéry, Fastrez Jacques, Soumillion Patrice
Abstract excerpt
In nature, the activity of many enzymes involved in important biochemical pathways is controlled by binding a ligand in a site remote from the active site. The allosteric sites are frequently located in hinge regulatory subunits, in which a conformational change can occur and propagate to the active site. The enzymatic activity is then enhanced or decreased depending on the type of effectors. Many artificial...
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