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Article

Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase BcII are inactive.

Biochemistry - 19 Aug 2008

Abriata Luciano A, González Lisandro J, Llarrull Leticia I, Tomatis Pablo E, Myers William K, Costello Alison L, Tierney David L, Vila Alejandro J

Abstract excerpt

Metallo-beta-lactamases (MbetaLs) are zinc enzymes able to hydrolyze almost all beta-lactam antibiotics, rendering them inactive, at the same time endowing bacteria high levels of resistance. The design of inhibitors active against all classes of MbetaLs has been hampered by their structural diversity and by the heterogeneity in metal content in enzymes from different sources. BcII is the metallo-beta-lactamase...

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PMID: 18652482
DOI: 10.1021/bi8006912
PMCID: PMC2565585

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