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Engineering allosteric protein switches by domain insertion

25 Jul 2005

Abstract excerpt

Domain insertion is proving to be an effective way to construct hybrid proteins exhibiting switch-like behavior. In this strategy, two existing domains, the first exhibiting a signal recognition function and the second containing the function to be modulated, are fused such that the recognition of the signal by the first domain is transmitted to the second domain, thereby modulating its activity. Recent directed...

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PMID: 16043448
DOI: 10.1093/protein/gzi048

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