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Article

Active-site mutants of class B beta-lactamases: substrate binding and mechanistic study.

Cellular and molecular life sciences : CMLS - 1 Dec 2002

Prosperi-Meys C, de Seny D, Llabres G, Galleni M, Lamotte-Brasseur J

Abstract excerpt

Increased resistance to beta-lactam antibiotics is mainly due to beta-lactamases. X-ray structures of zinc beta-lactamases unraveled the coordination of the metal ions, but their mode of action remains unclear. Recently, enzymes in which one of the zinc ligands was mutated have been characterized and their catalytic activity against several beta-lactam antibiotics measured. A molecular modeling study of these...

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Identifiers

PMID: 12568339
DOI: 10.1007/s000180200013
PMCID: PMC11146125

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