Article
HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection.
AIDS (London, England) - 31 Jul 2010
Gao Xiaojiang, O'Brien Thomas R, Welzel Tania M, Marti Darlene, Qi Ying, Goedert James J, Phair John, Pfeiffer Ruth, Carrington Mary
Abstract excerpt
OBJECTIVE: HLA class I polymorphism is known to affect the rate of progression to AIDS after infection with HIV-1. Here we test the consistency of HLA-B allelic effects on progression to AIDS, heterosexual HIV transmission, and 'set point' viral levels. METHODS: We used adjusted Cox proportional hazard models in previously published relative hazard values for the effect of HLA-B alleles on progression to AIDS (n...
Topics
- Adolescent
- Adult
- CD4-Positive T-Lymphocytes
- Disease Progression
- Europe
- Female
- Genotype
- HIV Seropositivity
- HIV-1
- HLA-B Antigens
- Hemophilia A
- Heterosexuality
- Humans
- Lymphocyte Activation