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Article

AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.

Nature medicine - 1 Dec 2005

Gao Xiaojiang, Bashirova Arman, Iversen Astrid K N, Phair John, Goedert James J, Buchbinder Susan, Hoots Keith, Vlahov David, Altfeld Marcus, O'Brien Stephen J, Carrington Mary

Abstract excerpt

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16288280
DOI: 10.1038/nm1333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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