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Article

Homology model of the DNA gyrase enzyme of Helicobacter pylori, a target of quinolone-based eradication therapy.

Journal of gastroenterology and hepatology - 1 May 2010

Matsuzaki Juntaro, Suzuki Hidekazu, Tsugawa Hitoshi, Nishizawa Toshihiro, Hibi Toshifumi

Abstract excerpt

BACKGROUND AND AIMS: Resistance of Helicobacter pylori to the standard therapeutic antimicrobial agents has been demonstrated. Although quinolones are an alternative candidate for third-line eradication therapy, quinolone resistance of H. pylori is also increasing. Quinolone resistance of H. pylori is caused by a point mutation of the DNA gyrase subunit A (GyrA) protein, especially on amino acids 87 and 91. The...

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Source

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PMID: 20586870
DOI: 10.1111/j.1440-1746.2010.06245.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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