Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid detection of point mutations conferring resistance to fluoroquinolone in gyrA of Helicobacter pylori by allele-specific PCR.

Journal of clinical microbiology - 1 Feb 2007

Nishizawa Toshihiro, Suzuki Hidekazu, Umezawa Ayako, Muraoka Hiroe, Iwasaki Eisuke, Masaoka Tatsuhiro, Kobayashi Intetsu, Hibi Toshifumi

Abstract excerpt

Helicobacter pylori strains with reduced susceptibility to fluoroquinolones have a mutation at either codon 87 Asn or 91 Asp of the gyrA gene. A rapid test based on an allele-specific PCR (AS-PCR) was designed to detect the gyrA mutations. Clinical H. pylori isolates were obtained from the stomachs of 51 patients with H. pylori infections who showed treatment failure. The MICs of gatifloxacin (GAT) were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to DNA Gyrase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Fluoroquinolones

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Microbial Sensitivity Tests

Share to Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 17122023
DOI: 10.1128/JCM.01997-06
PMCID: PMC1829027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid detection of point mutations conferring resistance to fluoroquinolone in gyrA of Helicobacter pylori by allele-specific PCR.PMID 17122023Read ↗

Improved allele-specific PCR assays for detection of clarithromycin and fluoroquinolone resistant of Helicobacter pylori in gastric biopsies: identification of N87I mutation in GyrASemantic proximity Read ↗

Update on fluoroquinolone resistance in Helicobacter pylori: new mutations leading to resistance and first description of a gyrA polymorphism associated with hypersusceptibility.Semantic proximity Read ↗

Mutations of Helicobacter pylori Associated with Fluoroquinolone Resistance in KoreaSemantic proximity Read ↗

Fluoroquinolone resistance in Helicobacter pylori: role of mutations at position 87 and 91 of GyrA on the level of resistance and identification of a resistance conferring mutation in GyrB.Semantic proximity Read ↗

Gatifloxacin-based triple therapy as a third-line regimen for Helicobacter pylori eradication.Semantic proximity Read ↗

Screening method for Salmonella enterica serovar Typhi and serovar Paratyphi A with reduced susceptibility to fluoroquinolones by PCR-restriction fragment length polymorphism.Semantic proximity Read ↗

Accelerated cycling PCR: A novel tool for rapid, sensitive and specific detection of single-nucleotide mutation within 30 min.Semantic proximity Read ↗

Homology model of the DNA gyrase enzyme of Helicobacter pylori, a target of quinolone-based eradication therapy.Semantic proximity Read ↗

Gatifloxacin resistance and mutations in gyra after unsuccessful Helicobacter pylori eradication in Japan.Semantic proximity Read ↗

Determination of mutations of the 23S rRNA gene of Helicobacter pylori by allele specific primer-polymerase chain reaction method.Semantic proximity Read ↗

Rapid detection of quinolone-resistant Salmonella by real time SNP genotyping.Semantic proximity Read ↗

Distribution of spontaneous gyrA mutations in 97 fluoroquinolone-resistant Helicobacter pylori isolates collected in France.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.