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Article

Nucleotide sequence of the gyrA gene and characterization of ciprofloxacin-resistant mutants of Helicobacter pylori.

Antimicrobial agents and chemotherapy - 1 Jan 1995

Moore R A, Beckthold B, Wong S, Kureishi A, Bryan L E

Abstract excerpt

PCR was used to amplify a 238-bp region from Helicobacter pylori which corresponded to the quinolone resistance-determining region in Escherichia coli. The gyrA gene of H. pylori was cloned and sequenced. An open reading frame of 2,478 nucleotides coded for a polypeptide of 826 amino acids with a calculated molecular mass of 92,508 Da. The amino acid sequence showed an overall 52% identity with other bacterial...

Topics

Amino Acid Sequence
Base Sequence
Ciprofloxacin
DNA Gyrase
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Gene Amplification
Helicobacter pylori
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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Identifiers

PMID: 7695290
DOI: 10.1128/AAC.39.1.107
PMCID: PMC162494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7695290-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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