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Mechanism of Metronidazole Resistance in Helicobacter pylori : Comparison of the rdxA Gene Sequences in 30 Strains

1 Aug 2000

Abstract excerpt

The rdxA gene of 30 independently isolated Helicobacter pylori strains was sequenced. A comparison of the rdxA sequences revealed a higher percentage of amino acid substitutions in the corresponding protein than in other housekeeping genes. Out of 122 point mutations, 41 were missense and 4 were nonsense. A resistant strain with a nucleotide insertion in the rdxA sequence was also found. With the exception of the...

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PMID: 10898705
DOI: 10.1128/aac.44.8.2207-2210.2000

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