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Article

KRN/I-Ag7 mouse arthritis is independent of complement C3.

Journal of clinical immunology - 1 Oct 2011

Tsao Patricia Y, Arora Vaishali, Ji Mei Qing, Wright Alexander C, Eisenberg Robert A

Abstract excerpt

BACKGROUND: KRN/I-A(g7) (KxB/N) is a mouse model of inflammatory arthritis, which resembles human rheumatoid arthritis. Arthritis in these animals is caused by autoreactivity to a ubiquitously expressed autoantigen, glucose-6 phosphate isomerase. Tolerance is broken at both the T cell and B cell level. The sera from KRN/I-A(g7) mice can induce mouse arthritis in healthy mice. Complement components of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21732014
DOI: 10.1007/s10875-011-9562-2
PMCID: PMC3196781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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