Article

Decrease in multiple complement protein levels is associated with the development of islet autoimmunity and type 1 diabetes

2023-07-16

Abstract excerpt

<h4>Summary</h4> Type 1 diabetes (T1D) is a chronic condition caused by autoimmune destruction of the insulin-producing pancreatic β-cells. While it is known that gene-environment interactions play a key role in triggering the autoimmune process leading to T1D, the pathogenic mechanism leading to the appearance of islet autoantibodies - biomarkers of autoimmunity – is poorly understood. Here we show that disruptio...

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Literature Corpus work: 6548074f-1b86-56e1-bbd9-5647472e0ee0
DOI: 10.1101/2023.07.13.23292628

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