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Article

Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006

Peng Qi, Li Ke, Patel Hetal, Sacks Steven H, Zhou Wuding

Abstract excerpt

Previous studies have found that deficiency of complement component C3 is associated with reduced T cell responses in several disease models including viral infection, autoimmune disease, and transplantation. However, the underlying mechanism is unclear. In this study, we demonstrate that dendritic cells (DCs) are able to synthesize C3 and this synthesis is required for the capacity of DCs to stimulate...

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Identifiers

PMID: 16517700
DOI: 10.4049/jimmunol.176.6.3330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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