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Article

Effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and cardiovascular disease: A meta-analysis.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jun 2024

Liu Sen, Wan Jindong, Wang Dan, Yang Yi, Fang Jie, Luo Tao, Liang Dengpan, Hu Jun, Hou Jixin, Wang Peijian

Abstract excerpt

BACKGROUND AND AIM: The impact of the loss-of-function (LOF) genetic variant PCSK9 R46L on glucose homeostasis and cardiovascular disease (CVD) remains uncertain, despite its established correlation with diminished blood cholesterol levels. This meta-analysis aimed at exploring the effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and CVD. METHODS AND...

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Identifiers

PMID: 38734541
DOI: 10.1016/j.numecd.2024.04.007

Genes

PCSK9

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and cardiovascular disease: A meta-analysis.PMID 38734541Read ↗

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