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Article

Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice.

Aging cell - 1 Feb 2017

Wu Ryan T, Cao Lei, Mattson Elliot, Witwer Kenneth W, Cao Jay, Zeng Huawei, He Xin, Combs Gerald F, Cheng Wen-Hsing

Abstract excerpt

Selenium (Se) is a trace metalloid essential for life, but its nutritional and physiological roles during the aging process remain elusive. While telomere attrition contributes to replicative senescence mainly through persistent DNA damage response, such an aging process is mitigated in mice with inherently long telomeres. Here, weanling third generation telomerase RNA component knockout mice carrying short...

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Identifiers

PMID: 27653523
DOI: 10.1111/acel.12529
PMCID: PMC5242309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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