Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.

The Journal of biological chemistry - 13 Mar 2009

Kovacs Werner J, Tape Khanichi N, Shackelford Janis E, Wikander Thomas M, Richards Michael J, Fliesler Steven J, Krisans Skaidrite K, Faust Phyllis L

Abstract excerpt

Regulation of hepatic cholesterol biosynthesis, lipogenesis, and insulin signaling intersect at the transcriptional level by control of SREBP and Insig genes. We previously demonstrated that peroxisome-deficient PEX2-/- mice activate SREBP-2 pathways but are unable to maintain normal cholesterol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 4
Share to Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Homeostasis

Share to Peroxisomes

Share to Sterol Regulatory Element Binding Protein 1

Share to Sterol Regulatory Element Binding Protein 2

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 19110480
DOI: 10.1074/jbc.M809064200
PMCID: PMC2652311

Genes

PEX2
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19110480-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.PMID 19110480Read ↗

Disturbed Cholesterol Homeostasis in a Peroxisome-Deficient PEX2 Knockout Mouse ModelSemantic proximity Read ↗

Peroxisome import stress impairs ribosome biogenesis and induces integrative stress response through eIF2α phosphorylationSemantic proximity Read ↗

Longitudinal study of liver disease progression in the PEX1-Gly844Asp mouse model of mild Zellweger Spectrum DisorderSemantic proximity Read ↗

Peroxisome biogenesis disorders.Semantic proximity Read ↗

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants.Semantic proximity Read ↗

Peroxisomal disorders.Semantic proximity Read ↗

Human disorders of peroxisome metabolism and biogenesis.Semantic proximity Read ↗

Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice.Semantic proximity Read ↗

PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation.Semantic proximity Read ↗

Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling.Semantic proximity Read ↗

Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH PathogenesisSemantic proximity Read ↗

Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological featuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.