Liver Sinusoidal Endothelium: A Microenvironment-Dependent Differentiation Program in Rat Including the Novel Junctional Protein Liver Endothelial Differentiation-Associated Protein-1

Abstract excerpt

UNLABELLED: Liver sinusoidal endothelium (LSEC) is a prime example of organ-specific microvascular differentiation and functions. Disease-associated capillarization of LSEC in vivo and dedifferentiation of LSEC in vitro indicate the importance of the hepatic microenvironment. To identify the LSEC-specific molecular differentiation program in the rat we used a two-sided gene expression profiling approach comparing...

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