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Liver specification of human iPSC-derived endothelial cells transplanted into mouse liver

1 Feb 2024

Abstract excerpt

Background & Aims Liver sinusoidal endothelial cells (LSECs) are important in liver development, regeneration and pathophysiology, but the differentiation process underlying their tissue-specific phenotype is poorly understood and difficult to study as primary human cells are scarce. The aim of this study was to use human induced pluripotent stem cell (hiPSC)-derived LSEC-like cells to investigate the...

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PMID: 38681862
DOI: 10.1016/j.jhepr.2024.101023

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