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Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells

11 Sept 2023

Abstract excerpt

Liver sinusoidal endothelial cells (LSECs) play a pivotal role in maintaining liver homeostasis and influencing the pathological processes of various liver diseases. However, neither LSEC-specific hallmark genes nor a LSEC promoter-driven Cre mouse line has been introduced before, which largely restricts the study of liver diseases with vascular disorders. To explore LSEC-specific hallmark genes, we compared the...

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PMID: 37696816
DOI: 10.1038/s41392-023-01621-2

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