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Article

Ligation detection reaction-TaqMan procedure for single nucleotide polymorphism detection on genomic DNA.

Analytical biochemistry - 15 Oct 2004

Borodina Tatiana A, Lehrach Hans, Soldatov Aleksey V

Abstract excerpt

In this article, we describe a genotyping approach applicable to both individual and multiplexed single nucleotide polymorphism (SNP) analysis, based on a ligation detection reaction (LDR) performed directly on genomic DNA. During the ligation, the biallelic state of the SNP locus is converted into a bimarker state of ligated detector oligonucleotides. The state of the markers is then determined by a 5'-nuclease...

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PMID: 15450807
DOI: 10.1016/j.ab.2004.05.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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