Oncometabolite? IDH1 Discoveries Raise Possibility of New Metabolism Targets in Brain Cancers and Leukemia

Abstract excerpt

Cancer and metabolism have been linked since the 1920s, when German biochemist Otto Warburg, M.D., Ph.D., observed that tumor cells rapidly take up glucose and convert most of it to lactate, even in the presence of oxygen—the “Warburg effect.” But until very recently, there were no solid links between mutations in metabolic genes and common cancers, casting doubt on metabolism's central role in the disease. Then...

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