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Article

Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma.

Oncogene - 1 Jan 2022

Alzial Gabriel, Renoult Ophelie, Paris François, Gratas Catherine, Clavreul Anne, Pecqueur Claire

Abstract excerpt

Brain tumors actively reprogram their cellular metabolism to survive and proliferate, thus offering potential therapeutic opportunities. Over the past decade, extensive research has been done on mutant IDH enzymes as markers of good prognosis in glioblastoma, a highly aggressive brain tumor in adults with dismal prognosis. Yet, 95% of glioblastoma are IDH wild-type. Here, we review current knowledge about IDH...

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PMID: 34764443
DOI: 10.1038/s41388-021-02056-1
PMCID: PMC8799461

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