EpiTOP--a proteochemometric tool for MHC class II binding prediction.

Abstract excerpt

MOTIVATION: T-cell epitope identification is a critical immunoinformatic problem within vaccine design. To be an epitope, a peptide must bind an MHC protein. RESULTS: Here, we present EpiTOP, the first server predicting MHC class II binding based on proteochemometrics, a QSAR approach for ligands binding to several related proteins. EpiTOP uses a quantitative matrix to predict binding to 12 HLA-DRB1 alleles. It...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Epitopes, T-Lymphocyte
• Share to Histocompatibility Antigens Class II