Article
OptiTope--a web server for the selection of an optimal set of peptides for epitope-based vaccines.
Nucleic acids research - 1 Jul 2009
Toussaint Nora C, Kohlbacher Oliver
Abstract excerpt
Epitope-based vaccines (EVs) have recently been attracting significant interest. They trigger an immune response by confronting the immune system with immunogenic peptides derived from, e.g. viral- or cancer-related proteins. Binding of these peptides to proteins from the major histocompatibility complex (MHC) is crucial for immune system activation. However, since the MHC is highly polymorphic, different...
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