Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity.

Journal of virology - 1 Jun 2001

Watanabe T, Watanabe S, Ito H, Kida H, Kawaoka Y

Abstract excerpt

Ion channel proteins are common constituents of cells and have even been identified in some viruses. For example, the M2 protein of influenza A virus has proton ion channel activity that is thought to play an important role in viral replication. Because direct support for this function is lacking, we attempted to generate viruses with defective M2 ion channel activity. Unexpectedly, mutants with apparent loss of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza A virus
Share to Ion Channels
Share to Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Orthomyxoviridae Infections

Share to Plasmids

Share to Viral Matrix Proteins

Share to Virion

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 11356973
DOI: 10.1128/JVI.75.12.5656-5662.2001
PMCID: PMC114278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity.PMID 11356973Read ↗

Influenza B virus M2 protein can functionally replace its influenza A virus counterpart in promoting virus replication.Semantic proximity Read ↗

Mutations in the membrane-proximal region of the influenza A virus M2 protein cytoplasmic tail have modest effects on virus replication.Semantic proximity Read ↗

Identification of a Novel Splice Variant Form of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct EctodomainSemantic proximity Read ↗

Direct measurement of the influenza A virus M2 protein ion channel activity in mammalian cells.Semantic proximity Read ↗

Reduced incorporation of the influenza B virus BM2 protein in virus particles decreases infectivity.Semantic proximity Read ↗

Transmembrane Domain Length of Influenza a Virus M2 Does Not Determine Its Non-Lipid Raft Localization.Semantic proximity Read ↗

The M2 Ectodomain Is Important for Its Incorporation into Influenza A VirionsSemantic proximity Read ↗

Tyrosines in the influenza A virus M2 protein cytoplasmic tail are critical for production of infectious virus particles.Semantic proximity Read ↗

Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes.Semantic proximity Read ↗

Proton and cation transport activity of the M2 proton channel from influenza A virus.Semantic proximity Read ↗

Palmitoylation of the Influenza A Virus M2 Protein Is Not Required for Virus Replication In Vitro but Contributes to Virus VirulenceSemantic proximity Read ↗

A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.