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Functional polymorphisms in apoptosis pathway genes and survival in patients with gastric cancer.

Environmental and molecular mutagenesis - 1 Jun 2014

Gu Dongying, Du Mulong, Tang Cuiju, Chu Haiyan, Xu Zhi, Huo Xinyin, Gong Weida, Tang Yongfei, Zhou Jianwei, Tong Na, Xu Yong, Zhang Zhengdong, Wang Meilin, Chen Jinfei

Abstract excerpt

The FAS, FAS ligand (FASL), and CASP8 are key regulators for apoptosis and their deregulations play an important role in carcinogenesis. However, the effects of promoter polymorphisms of the FAS, and FASL, and CASP8 genes on the survival of gastric cancer are unknown. In this study, we investigated the association of four polymorphisms (FAS -1377G>A, -670A>G, FASL -844C>T, and CASP8 -652 6N ins>del) with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24535941
DOI: 10.1002/em.21856

Genes

CASP8
FAS

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