Article
Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.
Pharmacogenetics and genomics - 1 Apr 2006
Li Chunping, Wu Wei, Liu Jia, Qian Lixin, Li Aiping, Yang Kehu, Wei Qingyi, Zhou Jianwei, Zhang Zhengdong
Abstract excerpt
BACKGROUND: FAS and FASLG together initiate apoptosis, which prevents tumor development. FAS and FASLG polymorphisms in the promoter regions can alter the transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS -1377G>A, -670A>G, and FASLG -844T>C polymorphisms are associated with risk of bladder cancer. METHODS: In a hospital-based case-control study of 216 case patients with newly...
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