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Article

Functional variants in cell death pathway genes and risk of pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2008

Yang Ming, Sun Tong, Wang Li, Yu Dianke, Zhang Xuemei, Miao Xiaoping, Liu Junniao, Zhao Dan, Li Hui, Tan Wen, Lin Dongxin

Abstract excerpt

PURPOSE: Fas-Fas ligand (FasL)-mediated death pathway is important in the life and death of immune cells and, therefore, influences immune surveillance of carcinogenesis. This study examined the association between functional variants of Fas (-1377G-->A and -670A-->G), FasL (-844T-->C), and caspase-8 (CASP8) six-nucleotide deletion polymorphism (-652 6N ins-->del) and risk of pancreatic cancer. EXPERIMENTAL...

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Source

Identifiers

PMID: 18483392
DOI: 10.1158/1078-0432.CCR-08-0177

Genes

CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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