Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fast-growing, non-infectious and intracellularly surviving drug-resistant Mycobacterium aurum: a model for high-throughput antituberculosis drug screening.

The Journal of antimicrobial chemotherapy - 1 Oct 2009

Gupta Antima, Bhakta Sanjib, Kundu Subir, Gupta Manish, Srivastava Brahm S, Srivastava Ranjana

Abstract excerpt

OBJECTIVES: Enoyl acyl-carrier-protein reductase (InhA), the primary endogenous target for isoniazid and ethionamide, is crucial to type-II fatty acid biosynthesis (FAS-II). The objectives of this study were first to generate InhA mutants of Mycobacterium aurum, secondly to characterize InhA-mediated isoniazid and ethionamide resistance mechanisms across those mutants and finally to investigate the interaction of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular Dichroism
Share to Colony Count, Microbial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Isoniazid

Share to Microbial Viability

Share to Mycobacterium

Share to Oxazines

Share to Protein Interaction Mapping

Source

Identifiers

PMID: 19656786
DOI: 10.1093/jac/dkp279

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fast-growing, non-infectious and intracellularly surviving drug-resistant Mycobacterium aurum: a model for high-throughput antituberculosis drug screening.PMID 19656786Read ↗

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Semantic proximity Read ↗

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.Semantic proximity Read ↗

Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.Semantic proximity Read ↗

Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.Semantic proximity Read ↗

Understanding the action of INH on a highly INH-resistant Mycobacterium tuberculosis strain using Genechips.Semantic proximity Read ↗

Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.Semantic proximity Read ↗

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.Semantic proximity Read ↗

Unlocking InhA: Novel approaches to inhibit Mycobacterium tuberculosis.Semantic proximity Read ↗

The mechanism of isoniazid killing: clarity through the scope of genetics.Semantic proximity Read ↗

Biochemical Characterization of Isoniazid-resistant Mycobacterium tuberculosis: Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?Semantic proximity Read ↗

Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the DrugSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.