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Article

Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2017

McNeil Matthew B, Dennison Devon, Shelton Catherine, Flint Lindsay, Korkegian Aaron, Parish Tanya

Abstract excerpt

Isoniazid inhibits Mycobacterium tuberculosis InhA and is a key component of drug regimens that treat tuberculosis. However, the high rate of resistance against isoniazid is a contributing factor to the emergence of multi-drug resistance strains of M. tuberculosis. The 4-hydroxy-2-pyridine NITD-916 is a direct inhibitor of M. tuberculosis InhA that has comparable efficacy to isoniazid in mouse models of TB...

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Identifiers

PMID: 29050761
DOI: 10.1016/j.tube.2017.09.003
PMCID: PMC5679704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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