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ATM-deficient thymic lymphoma is associated with aberrant <i>tcrd</i> rearrangement and gene amplification

21 Jun 2010

Abstract excerpt

Ataxia telangiectasia mutated (ATM) deficiency predisposes humans and mice to T lineage lymphomas with recurrent chromosome 14 translocations involving the T cell receptor alpha/delta (Tcra/d) locus. Such translocations have been thought to result from aberrant repair of DNA double-strand breaks (DSBs) during Tcra locus V(D)J recombination, and to require the Tcra enhancer (Ealpha) for Tcra rearrangement or...

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PMID: 20566716
DOI: 10.1084/jem.20100285

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ATM-deficient thymic lymphoma is associated with aberrant <i>tcrd</i> rearrangement and gene amplificationPMID 20566716Read ↗

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