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Article

ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaks

3 Apr 2007

Abstract excerpt

The ATM (ataxia telangiectasia mutated) protein plays a central role in sensing and responding to DNA double-strand breaks. Lymphoid cells are unique in undergoing physiologic double-strand breaks in the processes of Ig class switch recombination and T or B cell receptor V(D)J recombination, and a role for ATM in these processes has been suggested by clinical observations in ataxia telangiectasia patients as well...

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PMID: 17405860
DOI: 10.1073/pnas.0611222104

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ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaksPMID 17405860Read ↗

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