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Article

Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activation

3 Aug 2022

Abstract excerpt

Understanding the mechanisms promoting chromosomal translocations of the rearranging receptor loci in leukemia and lymphoma remains incomplete. Here we show that leukemias induced by aberrant activation of β-catenin in thymocytes, which bear recurrent Tcra/Myc-Pvt1 translocations, depend on Tcf-1. The DNA double strand breaks (DSBs) in the Tcra site of the translocation are Rag-generated, whereas the Myc-Pvt1...

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PMID: 35921443
DOI: 10.1073/pnas.2201493119

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