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Article

Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice

1 Sept 2000

Abstract excerpt

Atm-deficient mice (Atm(-/-)) recapitulate many aspects of the ataxia telangiectasia (AT) syndrome, including the susceptibility to tumors of lymphoid origin. To investigate the mechanism of tumorigenesis, we have examined a panel of 8 thymic lymphomas from Atm(-/-) mice. All Atm(-/-) tumors are of thymic lymphoblastoid origin, display an immature CD3(-) and CD4(+)/CD8(+) phenotype, and arise coincident with...

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Identifiers

PMID: 10961898
DOI: 10.1182/blood.v96.5.1940

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Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient micePMID 10961898Read ↗

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