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ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes

31 Oct 2006

Abstract excerpt

Mutations in ATM (ataxia-telangiectasia mutated) cause ataxia-telangiectasia (AT), a disease characterized by neurodegeneration, sterility, immunodeficiency, and T-cell leukemia. Defective ATM-mediated DNA damage responses underlie many aspects of the AT syndrome, but the basis for the immune deficiency has not been defined. ATM associates with DNA double-strand breaks (DSBs), and some evidence suggests that ATM...

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PMID: 17077325
DOI: 10.1182/blood-2006-05-020917

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