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Article

Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma.

Journal of cancer research and clinical oncology - 1 Apr 2011

Li Guoqiang, Wu Xiaofeng, Zhang Feng, Li Xiangcheng, Sun Beicheng, Yu Yue, Yin Aihong, Deng Lei, Yin Jie, Wang Xuehao

Abstract excerpt

OBJECTIVES: Costimulatory signals are essential for T-cell activation and hence play a very important role in antitumor immunity. B7 and 4-1BBL which belongs to tumor necrosis factor (TNF) family provide costimulatory interaction for T-cell activation and function. This study investigated the role of B7 and 4-1BBL in the amplification of tumor immunity by transduction of the B7-1, B7-2 and 4-1BBL into mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Interferon-gamma

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Source

Identifiers

PMID: 20563597
DOI: 10.1007/s00432-010-0905-9

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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