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Article

T-bet transduction enhances anti-tumor efficacy of IFN-producing dendritic cell (IKDC) against hepatocellular carcinoma via apoptosis induction.

Biochemical and biophysical research communications - 8 Jan 2021

Xu Jianguo, Liu Zumei, He Ke, Xiang Guoan

Abstract excerpt

Hepatocellular carcinoma (HCC) remains a public health challenge that requires dedication to develop new treatment options due to its high recurrence rate and poor prognosis. Interferon-producing killer dendritic cell (IKDC) is a subset of INF-γ secreting immune cells that modulates acquired immunity and possesses cytolytic ability. We modified IKDC isolated from the murine spleen with T-bet lentiviral...

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PMID: 33348079
DOI: 10.1016/j.bbrc.2020.11.118

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