Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Co-Introduced Functional CCR2 Potentiates In Vivo Anti-Lung Cancer Functionality Mediated by T Cells Double Gene-Modified to Express WT1-Specific T-Cell Receptor

18 Feb 2013

Abstract excerpt

BACKGROUND AND PURPOSE: Although gene-modification of T cells to express tumor-related antigen-specific T-cell receptor (TCR) or chimeric antigen receptor (CAR) has clinically proved promise, there still remains room to improve the clinical efficacy of re-directed T-cell based antitumor adoptive therapy. In order to achieve more objective clinical responses using ex vivo-expanded tumor-responsive T cells, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23441216
DOI: 10.1371/journal.pone.0056820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-Introduced Functional CCR2 Potentiates In Vivo Anti-Lung Cancer Functionality Mediated by T Cells Double Gene-Modified to Express WT1-Specific T-Cell ReceptorPMID 23441216Read ↗

Lung-targeted cytokine-coding RNA-lipoplexes induce T and NK cell-mediated anti-tumor immune responseSemantic proximity Read ↗

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivoSemantic proximity Read ↗

NK cells specifically TCR-dressed to kill cancer cellsSemantic proximity Read ↗

CAR-NK cells with dual targeting of PD-L1 and MICA/B in human lung cancer H1299 cell tumor modelSemantic proximity Read ↗

Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-βSemantic proximity Read ↗

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T cell responses during chronic viral infectionSemantic proximity Read ↗

Chimeric Antigen Receptor-Engineered Cell Membrane-Coated Nanoparticles Promote Dual-Targeted mRNA-Based Cancer Gene TherapySemantic proximity Read ↗

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targetingSemantic proximity Read ↗

Targeting Multiple Tumors Using T-Cells Engineered to Express a Natural Cytotoxicity Receptor 2-Based Chimeric ReceptorSemantic proximity Read ↗

Human IL-2 mutein with higher antitumor efficacy than wild type IL-2.Semantic proximity Read ↗

Generation of Murine Carcinoma Models with Functional Heterologous HER1 and/or HER2 Receptors for In Vivo Study of Specific TherapiesSemantic proximity Read ↗

Establishment of an immortalized T-cell line from lung cancer tissue: phenotypic and functional analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.