Article
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.
PLoS biology - 1 Nov 2004
Rudic R Daniel, McNamara Peter, Curtis Anne-Maria, Boston Raymond C, Panda Satchidananda, Hogenesch John B, Fitzgerald Garret A
Abstract excerpt
Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Gluconeogenesis is...
Topics
- ARNTL Transcription Factors
- Analysis of Variance
- Animal Feed
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Body Mass Index
- CLOCK Proteins
- Circadian Rhythm
- Corticosterone
- Diet